Epinephrine Is the First Line of Treatment for Severe Allergic Reactions (Anaphylaxis)
Epinephrine is the only treatment for a severe allergic reaction known as anaphylaxis (anna-fih-LACK-sis). Epinephrine comes in the form of easy-to-use auto-injectors. It is only available through a prescription by your doctor.
Children or adults who have severe food allergies need two of these auto-injectors with them at all times. For children, this might mean having more than one set of medicine. For example, the child may need to keep one set at school and one set at after-school care. Another set typically remains at home. For adults, two auto-injectors might be enough.
Use these links to jump to the information you need:
What types of auto-injectors are available?
What are the differences between the different brands?
What are other epinephrine options available?
How does it stop anaphylaxis?
What is the role of antihistamines in treating anaphylaxis?
How do you inject epinephrine?
What if you accidentally inject yourself?
What do you need to know about temperature storage?
Epinephrine auto-injectors are the treatment for anaphylaxis. Several epinephrine auto-injectors are now available in the United States. There are also generic versions. Each contains the drug epinephrine. But, each device has its own unique set of instructions for use. Understanding the differences is important so that you get the device you want and you know how to properly use it.
The chart below summarizes the key facts about each of the available epinephrine auto-injectors. More details are available at the manufacturers’ websites. These websites also have patient instructional videos.
Pharmacists must follow state and federal regulations when filling your prescription for epinephrine. You should keep this in mind when filling your prescription.
There are many states in which the pharmacist can substitute a generic form of the prescription. This must be on the prescription in writing. The pharmacist must also get a verbal approval from the doctor. If you or your doctor prefer to receive a specific brand name, your doctor must write the brand name and “DAW” (dispense as written) or “do not substitute” on the prescription. This notation prohibits the pharmacist from dispensing a generic form of the prescription. Before you leave the pharmacy, make sure the pharmacy fills your prescription exactly as you and your child’s doctor expects.
Remember to speak to your child’s doctor to determine which epinephrine product is best for your child. Each device operates differently. Make sure that you have been trained to use the device that you leave the pharmacy with. Also, you should review the training video for that device.
0.1 mg, 0.15 mg and
Eligible patients with commercial insurance can get AUVI-Q through their AUVI-Q Direct Delivery Service. U.S. residents with commercial insurance, including those with high-deductible plans, will be able to obtain AUVI-Q for $0 out-of-pocket. Order directly from Kaléo by giving the enrollment form to your doctor. AUVI-Q is also available free of charge to U.S. residents with a household income of less than $100,000 who do not have government or commercial prescription drug coverage through their kaléo Cares Patient Assistance Program. But patients who qualify for Medicaid may be able to receive AUVI-Q for free. Call 1-877-30-AUVI-Q for questions about eligibility.
0.15 mg and
Yes, see below
Copay card provides maximum
benefit of $300 per EpiPen®
two-pack and can be redeemed up to six times. The site states the savings card expires Dec. 31, 2018. But according to a Mylan representative, you can still download and use the savings card. If your pharmacy does not accept the card, your pharmacist can call Mylan to confirm at 800-657-7613 (8 am-8 pm EST, Monday-Friday). Mylan also has a Patient Assistance Program.
0.15 mg and
Copay card provides maximum benefit of up to $25 off in savings per two-pack and can be used up to three times. The site states the savings card expires Dec. 31, 2018. But according to a Mylan representative, you can still download and use the savings card. If your pharmacy does not accept the card, your pharmacist can call Mylan to confirm at 800-657-7613 (8 am-8 pm EST, Monday-Friday).
Patients can register on the product website for an e-mail reminder when their medicine will expire.
0.15 mg available in 2019
Teva Pharmaceutical Industries
0.15 mg and
Distributed by Lineage Therapeutics
Copay card provides maximum benefit of $25 per two-pack.
Training devices are available for free via web or telephone.
*Available as a single injection or a two-pack.
** Epinephrine, USP auto-injector is the authorized generic of Adrenaclick (not currently available).
Other Epinephrine Options
There are other options that do not auto-inject the epinephrine. Glass vials of epinephrine with needles/syringes may be in emergency kits as seen on airplanes. There is also a new pre-filled syringe device that you can use to inject epinephrine. This device works differently than the auto-injectors. Be sure to have your doctor, nurse or pharmacist demonstrate how to use your device.
0.15 mg and 0.3 mg
Sandoz Inc., a Novartis Division
With insurance, SYMJEPI Savings Program covers up to $300 per prescription, up to $1,000 per year. Eligible patients may pay as little as $0. People without insurance coverage receive $100 off each prescription.
Kids With Food Allergies (KFA), a division of the Asthma and Allergy Foundation of America, hosted a free educational webinar on Feb. 26, 2014, featuring two of our medical advisors, Michael Pistiner, MD, and Angela Nace, PharmD. They discussed:
Unfortunately, some people cannot afford to buy this potentially life-saving medicine. If this is the case for you, there are options to help. On our blog, we offer up-to-date details about:
- Savings programs
- Pharmacy differences
- Insurance preferences
- Other sources of assistance
Blog: What to Do If You Can’t Afford Epinephrine
Up to 25% of severe allergic reactions that occur on school campuses happen to people who are experiencing their very first anaphylaxis reaction. Since these people (children, staff and visitors) have not been previously diagnosed with allergies, they may not have their own epinephrine auto-injectors on hand. Most states have passed legislation to allow schools to stock undesignated epinephrine as a part of their emergency medical kits. This allows specified staff to treat someone suffering anaphylaxis, even for their very first allergic reaction. Many states are looking beyond the classroom to other areas where food allergy triggers could be present. In any public space where food is present – such as sports and recreation venues, summer camps, amusement parks, movie theaters – there is a risk for an allergic person to come in contact with their allergen. To find out the status of epinephrine laws in your state, visit www.aafa.org/epinephrine.
Children show their support for Pennsylvania’s epinephrine stocking bill.
Related Epinephrine Resources
1. Product information for AUVI-Q. kaléo, Richmond, VA 23219. July 2019.
2. Product information for EpiPen. Mylan Inc. Basking Ridge, NJ 07920. July 2019.
3. Epinephrine Injection, USP auto-injector, the authorized generic (AG) of EpiPen®, Mylan Inc. Basking Ridge, NJ 07920. July 2019.
4. Product information for Epinephrine Injection, USP autoinjector, the authorized generic (AG) of Adrenaclick™. Lineage Therapeutics. Horsham, PA 19044. July 2019..
Medical review February 2014, June 2014, January 2015. Updated January 2016, August 2016, December 2016, January 2017, February 2017 and July 2019.